The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived ...

In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, ...

Principle guided design of glycan processing enzyme inhibitors involves embedding aromatic group onto charge and shape mimics. Intramolecular azide-alkyne cycloaddition was used as a simple and versatile strategy for the ...

A green methodology utilizing natural auxiliary like L-Arginine in conjunction with water and oxygen led to oxidative coupling of thiols into disulfides (S-S bond) whereas thiol-yne coupling (TYC) to access vinyl sulfides ...

Here, we describe a molecular hybridization inspired design and synthesis of novel 6-triazolyl 2,3,6-trideoxy sugars as promising new broad-spectrum antimicrobial agents using click chemistry in key step. These compounds ...

The current manuscript describes conformational analysis of 15-membered cyclic tetrapeptides (CTPs), with 3 architecture, containing sugar amino acids (SAA) having variation in the stereocenter at C5 carbon. Conformational ...

Gliptins, commonly known as clinical DPP-IV inhibitors have become a new class of potential drug candidate and are being hoped as a permanent eraser for type 2 diabetes. Therefore, gliptins have been a centre of research ...

DEAD Box RNA helicases are essential enzymes that are involved in RNA metabolic processes such as, transcription, pre-mRNA splicing, translation initiation, and RNA decay. We had earlier overexpressed and biochemically ...

The dimethylamino functionality is generally introduced onto the 3,5-dihydro-4H-imidazol-4-one skeleton by treatment of a halogenated derivative with low-boiling dimethylamine at a high temperature and pressure. The ...

Medicinal chemistry, an important branch of chemical sciences, serving the mankind by helping them to overcome, conditions unfavorable for their survival has fascinated the scientific community throughout the world. The ...