Cancer is a multi-stage complex disease involving a cumulative series of gene-environmental interactions leading to dysfunction in multiple mechanisms including machinery for DNA repair, apoptotic and immune responses. ...

The field of infectious diseases is ever changing with emerging pathogens, globalization, growing antimicrobial resistance, expanding therapeutic options and continuous development of vaccines and strategies for drug ...

Leishmaniasis (cutaneous, mucocutaneous, and visceral) is caused by an intracellular protozoan parasite complex by the invasion of the reticuloendothelial system (spleen, liver and bone marrow). Leishmaniasis is a zoonotic ...

The complexity and structural diversity of natural products have fascinated organic chemists for a very long time. The development of new types of chemical reactions over the past few decades has enabled synthetic chemists ...

The thesis entitled “Design, Synthesis and Conformational Studies of Peptidomimetics Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of Epoxyolefins in Natural Product Synthesis” consists ...

A series of seventeen novel 1,2,3-Triazole derivatives were efficiently synthesized in excellent yields by the popular ‘click chemistry’ approach and evaluated for their in vitro anti-tubercular activity against Mycobacterium ...

Drug discovery and development is a multidisciplinary process. Among different steps in the process, the first step is the lead generation which involves the design and synthesis of the bioactive molecules. The synthetic ...

The 4‐Hydroxyisoleucine (4‐HIL), an unusual amino acid isolated from the seeds of Trigonella foenum‐graecum was investigated for the metabolic effects to ameliorate free fatty acid‐induced insulin resistance in skeletal ...

There are many chemotherapeutic interventions available for tuberculosis (TB) and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant ...

Rohitukine (RH) is a chromone alkaloid considered as one of the major active components of Dysoxylum binectariferum, exhibiting diverse pharmacological activities such as anti-hyperlipidmic, anti-cancer, anti-inflammatory, ...