Antifungal Activity of Some Sulphur Containing Compounds against Dermatophytes & Yeast-like Fungi

Abstract

The antifungal activity of a copper chelate of a suiphone hydrazide, two sulphoxides (ρ-methylamino – ρ' - aminodiphenyl and ρ -amylamino- ρ' -aminodiphenyl), three sulphides (diaminodiphenyl, ρ -methylamino- ρ -aminodiphenyl and ρ -ethylamino- ρ' -aminodiphenyl) and a potassium salt of benzyl isothiocyanate sulphonic acid were tested against five dermatophytes (Trichophyton rubrum, T. sulfureum, T. mentagrophytes, Microsporum audouini and M. gypseum) and three yeast-like fungi (Candida albicans, Geotrichum sp. and Trichosporon cutanettm) using undecylenic acid as the standard. The potassium salt of benzyl isothiocyanate sulphonic acid completely inhibited the growth of all the fungi except M. audouini, It appears to be superior to undecylenic acid against seven fungi but not against M. audouini, ρ -Methylamino- ρ' aminodiphenyl and p-ethylamino- ρ' -aIDinodiphenyl sulphides completely inhibited the growth of T. rubrum, T. sulfureum, T. mentagrophytes, Geotrichum sp, and Trichosporon cutaneum at certain concentrations but had little or no effect on M. audouini, M. gypseum and C. albicans. Diaminodiphenyl sulphide and the two sulphoxides were able to stop the growth of T. rubrum, T. sulfureum and T. mentagrophytes only at the, highest concentration used. Copper chelate of the suiphone hydrazide did not show much activity.