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2D Gel Electrophoresis based Proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK mediated apoptosis in chronic myeloid leukemia cells K562

Pal, Pooja; Kanaujiya, J K; Lochab, Savita; Tripathi, S B; Bhatt, M L B; Singh, P K; Sanyal, Sabyasachi; Trivedi, A K (2011)

Ormeloxifen is a non-steroidal selective estrogen receptor modulator (SERM) and has been shown to possess anticancer activities in breast and uterine cancer. Here, we show that ormeloxifen induces apoptosis in dose dependent ...
Influence of vehicles used for oral dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice

Singh, Shubhra; Dwivedi, Richa; Chaturvedi, Vinita (2012)

Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl ...
E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin mediated proteasome degradation

Pal, Pooja; Lochab, Savita; Kanaujiya, J K; Kapoor, Isha; Sanyal, Sabyasachi; Behre, Gerhard; Trivedi, A K (2013)

CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is an important transcription factor involved in granulocytic differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase targets C/EBPα for ...
SOLiDTM Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key Questions

Singh, Neeloo; Chikara, Surendra; Sundar, Shyam (2013)

Background: Known as ‘neglected disease’ because relatively little effort has been applied to finding cures, leishmaniasis kills more than 150,000 people every year and debilitates millions more. Visceral leishmaniasis ...
Chemokine Receptor Trio: CXCR3, CXCR4 and CXCR7 Crosstalk via CXCL11 and CXCL12

Singh, A K; Arya, R K; Trivedi, A K; Sanyal, Sabyasachi; Baral, Rathindranath; Dormond, Olivier; Briscoe, D M; Datta, Dipak (2013)

Although chemokines are well established to function in immunity and endothelial cell activation and proliferation, a rapidly growing literature suggests that CXC Chemokine receptors CXCR3, CXCR4 and CXCR7 are critical in ...
E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha

Pal, Pooja; Lochab, Savita; Kanaujiya, J K; Kapoor, Isha; Sanyal, Sabyasachi; Behre, Gerhard; Trivedi, A K (2013)

CCAAT/Enhancer Binding Protein Alpha (C/EBPa) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits adipocyte differentiation ...

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