Background Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of newer anti-malarial combination(s) and selection of ...

The dose escalation pharmacokinetic of 16-Dehydropregnenalone and its major metabolite 5-pregnene-3β-ol-16,17-epoxy-20-one (M1) by intravenous and oral administration were studied in SD rats. Plasma concentration profile ...

A rapid and sensitive LC/MS/MS method was developed for the quantification of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from tear sample by solid ...

We designed a series of twenty five 3-(azol-1-yl)phenylpropanes which yielded ten compounds (3,4,7,8,13,14,19,21,23,26) that irreversibly immobilized 100% human sperm at 1% (w/v) concentration in 60 seconds; twelve compounds ...

Hypolipidemic and anti-obesity effects of the newly synthesized indole-based fibrates were evaluated in Triton WR-1339 and HFD-induced hyperlipidemic rats. Preliminary screening of all the synthesized compounds was done ...

Metronidazole (MTZ), the FDA approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance; while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen ...

Syntheses of a variety of aza-polycycles employing 2-(N-allylaminomethyl)cinnamaldehydes derived from Morita-Baylis-Hillman adducts of acrylates via intramolecular 1,3-dipolar cycloaddition, or Aza-Diels-Alder or domino ...

A simple, sensitive and specific reversed phase high performance liquid chromatographic (RP-HPLC) method for simultaneous determination of atenolol, paracetamol, hydrochlorothiazide, caffeine, cephalexin, metoprolol, ...

The aim of this study was to prepare natamycin encapsulated lecithin/chitosan mucoadhesive nanoparticle (NPs) for prolonged ocular application. These NPs were characterized by their mean particle size 213 nm, encapsulation ...