CSIR-CDRI Publications: Recent submissions

Now showing items 401-420 of 1093

Daidzein Prevents the Increase in CD4+CD28null T Cells and B Lymphopoesis in Ovariectomized Mice: A Key Mechanism for Anti-Osteoclastogenic Effect

Tyagi, A M; Srivastava, Kamini; Sharan, Kunal; Yadav, Dinesh; Maurya, Rakesh; Singh, Divya (2011)

Estrogen deficiency leads to an upregulation of TNF-a producing T cells and B-lymphopoesis which augments osteoclastogenesis. Estrogen deficiency also increases the population of premature senescent CD4+CD28null T cells ...
SOLiDTM Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key Questions

Singh, Neeloo; Chikara, Surendra; Sundar, Shyam (2013)

Background: Known as ‘neglected disease’ because relatively little effort has been applied to finding cures, leishmaniasis kills more than 150,000 people every year and debilitates millions more. Visceral leishmaniasis ...
Strong Association of 677 C.T Substitution in the MTHFR Gene with Male Infertility - A Study on an Indian Population and a Meta-Analysis

Gupta, Nishi; Gupta, Saraswati; Dama, Madhukar; David, Archana; Khanna, Geeta; Khanna, Anil; Singh, Rajender (2011)

Background: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for DNA synthesis and methylation. The objective of this study was to analyze MTHFR gene ...
Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice

Singh, Prabhat; Mishra, S K; Noel, Sanjeev; Sharma, Sharad; Rath, Srikanta Kumar (2012)

Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. Toxicity of Apigenin is however, least explored, and reports are scanty in literature. This warrants ...
HIV-1 Nef Breaches Placental Barrier in Rat Model

Singh, Poonam; Agnihotri, S K; Tewari, M C; Kumar, Sadan; Sachdev, Monika; Tripathi, R K (2012)

The vertical transmission of HIV-1 from the mother to fetus is known, but the molecular mechanism regulating this transmission is not fully characterized. The fetus is highly protected by the placenta, which does not permit ...
Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis

Tyagi, A M; Srivastava, Kamini; Mansoori, M N; Trivedi, Ritu; Chattopadhyay, Naibedya; Singh, Divya (2012)

Th17 cells produce IL-17, and the latter promotes bone loss in collagen-induced arthritis in mice. Blocking IL-17 action in mouse model of rheumatoid arthritis reduces disease symptoms. These observations suggest that ...
Characterization of antimicrobial, cytotoxic and anti-endotoxin properties of short peptides with different hydrophobic amino acids at ‘a’ and ‘d’ positions of a heptad repeat sequence

Azmi, Sarfuddin; Srivastava, Saurabh; Mishra, N N; Tripathi, J K; Shukla, P K; Ghosh, J K (2013)

To understand the influence of different hydrophobic amino acids at ‘a’ and ‘d’ positions of a heptad repeat sequence on antimicrobial, cytotoxic and anti-endotoxin properties, four fifteen-residues peptides with leucine ...
Synthesis and biological evaluation of a new class of 4-aminoquinoline- rhodanine hybrid as potent anti-infective agents

Chauhan, Kuldeep; Sharma, Moni; Saxena, Juhi; Singh, S V; Trivedi, Priyanka; Srivastava, Kumkum; Puri, S K; Saxena, J K; Chaturvedi, Vinita; Chauhan, P M S (2013)

Synthesis of novel 4-aminoquinoline-rhodanine hybrid using inexpensive starting materials via easy to operate methodology, and their biological activity is reported. All the compounds were screened for their in vitro ...
Structural insights into putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv

Srivastava, V K; Srivastava, Shubra; Arora, Ashish; Pratap, J V (2013)

The Molybdenum cofactor (Moco) biosynthesis pathway is an evolutionary conserved pathway seen in almost all eukaryotes including the pathogenic species Mycobacterium tuberculosis. This pathway comprises of several novel ...
Development and Validation of Improved HPLC Method for the Quantitative Determination of Curcuminoids in Herbal Medicament

Malasoni, Richa; Srivastava, Akansha; Pandey, R R; Srivastava, P K; Dwivedi, A K (2013)

A simple and precise high performance liquid chromatography (HPLC) method was developed and validated for simultaneous trace analysis of the content of pharmacologically important active curcuminoids: curcumin (C), ...
Microwave assisted three component domino reaction: Synthesis of Indolodiazepinotriazoles

Arigela, R K; Sharma, S K; Kumar, Brijesh; Kundu, Bijoy (2013)

A microwave assisted three component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide and intramolecular Huisgen azide/internal alkyne 1,3-dipolar ...
One pot conversion of Carbohydrates alcohol in to chloride via benzotriazole sulfonate

Azad, C S; Saxena, A K (2013)

A one pot method for chloro-dehydroxylation of carbohydrates alcohol electrically hindered ones in excellent yield was developed. The proposed to play a crucial role in the reaction medium which undergoes ion in the ...
Expeditious synthesis of chiral 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazines

Bhowmik, Subhendu; Kumar, A K S; Batra, Sanjay (2013)

An expeditious one-pot two-step synthesis of chiral 4-substituted-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-ones via reaction between 5-methyl furfurylamine and N-Boc amino acids is described. LiAlH4-mediated reduction ...
In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi

Singh, P K; Kushwaha, Susheela; Shahab, Mohd.; Pathak, Manisha; Bhattacharya-Misra, Shailja (2013)

Background: The phosphoglycerate mutase (PGM) enzyme catalyzes the interconversion of 2- and 3-phosphoglycerate in the glycolytic /gluconeogenic pathways that are present in the majority of cellular organisms. They can be ...
Regioselective synthesis of densely functionalized, enantiopure, sugar-pyrazole hybrids as potential scaffolds for drug discovery

Saquib, Mohammad; Husain, Irfan; Kant, Ruchir; Meena, Sanjeev; Gauniyal, H M; Sinha, Sudhir; Maulik, P R; Shaw, A K (2013)

A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar-pyrazole hybrid molecules with multiple sites for structural diversification and non-flat skeleton as ...
Synthesis of Perspicamide A and Related Diverse Analogues: Their Bio-evaluation as Potent Antileishmanial Agents

Pandey, A K; Sharma, Rashmi; Shivahare, Rahul; Arora, Ashish; Rastogi, Neeraj; Gupta, Suman; Chauhan, P M S (2013)

The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues 24a, 24b, 24c, 24d ...
Cloning, characterization and sub-cellular localization of gamma subunit of T-complex protein1 (chaperonin) from Leishmania donovani

Bhaskar; Kumari, Neeti; Goyal, Neena (2012)

T-complex protein-1 (TCP1) complex, a chaperonin class of protein, ubiquitous in all genera of life, is involved in intracellular assembly and folding of various proteins. The gamma subunit of TCP1 complex (TCP1γ), plays ...
Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase

Khan, S R; Singh, Supriya; Roy, K K; Akhtar, M S; Saxena, A K; Krishnan, M Y (2013)

The ATP synthase of Mycobacterium tuberculosis is a validated drug target against which a diarylquinoline drug is under clinical trials. The enzyme is crucial for the viability both of actively replicating and non-replic ...
Testicular Recovery from Chronic Suppressive Effects of Estrogen in Hyperthyroid Guinea-pigs

Dasgupta, P R; Kar, A B; Das, G (1963)
Pharmacognosy of Piplamul' - the Root and Stem of Piper Longum Linn.

Bisht, B S (1963)

Now showing items 401-420 of 1093

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