CSIR-CDRI Publications: Recent submissions

Now showing items 201-220 of 1093

PKCδ-IRAK1 axis regulates oxidized LDL induced IL-1β prod uction in monocytes

Tiwari, R L; Singh, Vishal; Singh, Ankita; Rana, Minakshi; Verma, Anupam; Kothari, Nikhil; Kohli, Monica; Bogra, Jaishri; Dikshit, Madhu; Barthwal, M K (2014)

Present study examined the role of IL-1R-associated kinase (IRAK) and protein kinase C (PKC) in Oxidized LDL (Ox-LDL) induced monocyte IL-1β production. In THP1 cells Ox-LDL induced time dependent secretory IL-1β, IRAK1 ...
Molecular characterization of an rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi and antifilarial activity of specific inhibitors of the enzyme

Rana, A K; Chandra, Sharat; Siddiqi, M I; Bhattacharya-Misra, Shailja (2013)

The endosymbiotic Wolbachia of Brugia malayi are an attractive antifilarial drug target. These bacteria possess an mutualistic relationship with the filarial parasite and impair filarial growth and survival if treated with ...
Rohitukine inhibits in vitroadipogenesis arresting mitotic clonal expansionand improves dyslipidemia in vivo

Varshney, Salil; Shankar, Kripa; Beg, Muheeb; Balaramnavar, V M; Mishra, S K; Jagdale, Pankaj; Srivastava, Shishir; Chhonker, Y S; Lakshmi, Vijai; Chaudhari, B P; Bhatta, R S; Saxena, A K; Gaikwad, A N (2014)

We developed a common feature pharmacophore model using known anti-adipogenic compounds (CFPMA). We identified rohitukine, a reported chromone anti-cancer alkaloid as potential hit through in silico mapping of in-house ...
Tandem Cu-Catalyzed Ketenimines formation and Intramolecular Nucleophile Capture: Synthesis of 1,2-dihydro-2-Iminoquinolines from 1-(o-acetamidophenyl)-Propargyl Alcohols

kumar, G R; Kumar, Y K; Kant, Ruchir; Reddy, M S (2014)

The copper catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl)-propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2-im ...
Metabolic profiling of piper species by direct analysis in real time mass spectrometry combined with principal component analysis

Chandra, Preeti; Bajpai, Vikas; Srivastva, Mukesh; Kumar, K B R; Kumar, Brijesh (2014)

Piper nigrum (Black pepper), Piper longum (Indian tipali) and Piper chaba (Bangla tipali) are widely used medicinal herbs in traditional Indian systems of medicine. P. longum as well as P. chaba are considered as the ...
Nucleosomal Histone Proteins of L. donovani: A combination of recombinant H2A, H2B, H3 and H4 proteins were highly immunogenic and offered optimum prophylactic efficacy against Leishmania challenge in hamsters

Baharia, R K; Tandon, Rati; Sahasrabuddhe, A A; Sundar, Shyam; Dube, Anuradha (2014)

The present study includes cloning and expression of recombinant L.donovani histone proteins (rLdH2B, rLdH3, rLdH2A and rLdH4), assessment of their immunogenicity in Leishmania infected cured patients/endemic contacts as ...
Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood

Kumar, Padam; Kushwaha, Priyanka; Khedgikar, Vikram; Gautam, Jyoti; Choudhary, Dharmendra; Singh, Divya; Trivedi, Ritu; Maurya, Rakesh (2014)

The present study was undertaken to investigate and rationalize the in-vitro antiosteoporotic activity of neoflavonoids, isolated from Dalbergia sissoo heartwood. Neoflavonoids were isolated using extensive column ...
Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine

Avasthi, Kamlakar; Shukla, Lakshmi; Kant, Ruchir; Ravikumar, Krishnan (2014)

Abstract Butylidene linker models 1-(2-(2,6-dimethylsulfanyl-9H-purin-9-yl)-2-methylenepropane-4,6-dimethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine, (XI), C18H20N8S4, 7,7′-(2-methylenepropane-1,3-diyl)bis(3-methyl-2-methyl ...
Recent advances in the synthesis, chemical transformations and pharmacological studies of some important dietary spice’s constituents

Singh, V K; Yadav, Pragya; Tadigoppula, Narender (2014)

Chemoprevention, a relatively new and promising strategy to prevent various human disorders, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process ...
Ethnopharmacological survey on bone healing plants with special reference to Pholidota articulata and Coelogyne cristata (Orchidaceae) used in folk tradition of Kumaon, Uttarakhand, India

Sharma, Chetan; Kumari, Tejaswita; Arya, K R (2014)

Aim: This study was aimed to conduct an ethnopharmacological survey and document the medicinal plant used for healing fractures in folk tradition of Kumaon, Uttarakhand, India. Materials and methods: The Ethnopharmacological ...
Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones

Gupta, P K; Hussain, M K; Asad, Mohd.; Kant, Ruchir; Mahar, Rohit; Shukla, S K; Hajela, Kanchan (2014)

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl ...
Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics

Gupta, Ankit; Shah, Priyanka; Haider, Afreen; Gupta, Kirti; Siddiqi, M I; Ralph, S A; Habib, Saman (2014)

Apicomplexan protists such as Plasmodium and Toxoplasma contain a mitochondrion and a relic plastid (apicoplast) that are sites of protein translation. Although there is emerging interest in the partitioning and function ...
Microwave Assisted [RuCl2(p-cymene)2]2 Catalyzed Regioselective Endo-Tandem Cyclization Involving Imine and Alkyne Activation: An Approach to benzo[4,5]imidazo[2,1-a]pyridine Scaffold

Manna, S K; Panda, Gautam (2014)

A microwave assisted efficient route to the synthesis of benzimidazole fused heterocycles through metal catalyzed endo-cyclization strategy involving imine and alkyne activation has been developed. In the presence of ...
New convenient synthesis of fluorescent 1,8-Naphthyridines and their metal- sensing properties

Goel, Atul; Nag, Pankaj; Umar, Shahida (2014)

A new efficient approach to a series of highly fluorescent non-aggregating donor-acceptor [1,8]-naphthyridines is described. Photophysical properties of [1,8]-naphthyridines revealed that the presence of donor-acceptor ...
Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes

Singh, S K; Malhotra, Soniya; Akhtar, M S (2014)

Streptococcus pyogenes is associated with a wide variety of mucosal and invasive infections that claim human life. The conversion from non pathogenic to toxigenic strain of S. pyogenes are thought to be mediated by ...
An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita-Baylis-Hillman adducts

Bhowmik, Subhendu; Bhattacharyya, Soumya; Batra, Sanjay (2014)

An acid-catalyzed modular synthesis of substituted 5H-dibenz [c,e]azepines from a biaryl allyl benzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility ...
Modelling Biding Affinity of Steroids to Zebrafish Sex Hormone Binding Globulin

Saxena, A K; Devillers, J; Pery, A R R; Beaudouin, R; Balaramnavar, V M; Ahmed, S (2014)

The circulating endogenous steroids bound to a highly specific sex hormone-binding globulin (SHBG) and in lower-affinity to the proteins like the corticosteroid-binding protein and albumin in vertebrate including fish are ...
Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells

Khan, M F; Maurya, C K; Dev, Kapil; Arha, Deepti; Rai, A K; Tamrakar, A K; Maurya, Rakesh (2014)

Structure modifications of lupeol at the isopropylene moiety have been described via allylic oxidation using selenium dioxide. The antidiabetic efficacy of lupeol analogues were evaluated in vitro as glucose uptake stimulatory ...
Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors

Murugesan, Vanangamudi; Makwana, Nandini; Suryawanshi, Rahul; Saxena, Reshu; Tripathi, Rajkamal; Paranjape, Ramesh; Kulkarni, Smita; Katti, S B (2014)

A series of novel thiazolidin-4-one analogues, characterized by different substitution patterns at positions C-2 and N-3 of the thiazolidin-4-one scaffold for anti-HIV-1 activity has been investigated. Most of the compounds ...
A rapid entry to amino acids derived diverse 3,4-dihydropyrazines and ihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition

Bera, Saurav; Panda, Gautam (2014)

An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acids ...

Now showing items 201-220 of 1093

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