Synthesis of Novel Heterocycles as Possible Anticancer and Antiparasitic Agents

Abstract

Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues. Despite a better understanding of the disease and the advent of modern technology and rationally targeted drugs, the incidence and cure rate of cancer have not improved. On the other hand, Parasitic diseases represent major global health problems of immense proportion. Diseases caused by protozoan and helminth parasites are among the leading causes of death and disease in tropical and subtropical regions of the world. Controlling parasitic diseases is problematic as no vaccines are available for any of them. Further, efforts to control the invertebrate vector of these diseases are difficult due to pesticide resistance and lack of adequate infrastructure to apply existing vector control methods. Thus, control of these diseases relies heavily on the chemotherapy. Unfortunately, existing therapeutics are insufficient as they are either incompletely effective or toxic to the human host and also even safe and effective drugs are failing as a result of drug resistant variants of the parasites. It is well known fact that the heterocycles have played an important role in earlier period of human life and they still have much importance at present and in future too. Due to the vast biological importance of nitrogen containing heterocycles like triazine, indole, pyridine, β-carboline and quinoline derivatives, the synthesis of these heterocyclic ring systems and their derivatives has been excessively targeted in my dissertation work which can be lead as a strong drug candidate in the field of cancer and parasitic disease like malaria, leishmania and tuberculosis. Chapter 1 reviews the nitrogen containing heterocycles as anticancer agents. Chapter 2 deals the basis of the work which confirming has been done during the entire period of the course. The chapter 3 describes the chemistry involved in the synthesis of various intermediates and final compounds, while chapter 4 includes their biological evaluation as anticancer, antimalarial, antitubercular, antileishmanial and antibacterial agents. Chapter 5 reviews biologically active bis and tris indole alkaloids from marine organism and also included the synthesis of marine alkaloid 8,9- dihydrocoscinamide B, its analogues as potent antileishmanial agents. All the tables are numbered serially and each chapter provides the relevant references.