Design and Synthesis of Novel Nitrogen Heterocyclic prototypes and their Antiparasitic and Antimicrobial activity

Abstract

The field of infectious diseases is ever changing with emerging pathogens, globalization, growing antimicrobial resistance, expanding therapeutic options and continuous development of vaccines and strategies for drug implementation. At the present time, Infectious diseases affects more than one billion people (one-sixth of the world’s population) with almost 550 000 deaths annually. Malaria, Leishmania and antimycobacterial are considered to be the one of the most widespread infectious disease. The chemotherapy of these diseases is still dependent on the drugs got resistance or become ineffective and several side effects or cost effective. For these reasons, the search for novel molecules with effective results and resistance resolving efficacy is the prime choice for the medicinal chemists. Mechanism specific studies of these molecules will be also helpful to overcome the problem of emerging resistance and chemical modification led to enhance efficacy. Here we made an attempt for the synthesis of novel heterocycles like 1,3,5-triazine, tetrazole, rhodanine, quinoline and quinolone and their spiro derivatives, as they have already established as a safe, effective and promising anti-infective agents and screened for a verity of infectious diseases