Synthesis of a variety of pyrazole-fused systems starting from 4-iodopyrazolecarbaldehydes is described. The general strategy involves Suzuki coupling of 2-formyl aryl boronic acid with the 4-iodopyrazole derivatives ...

Background: Antituberculosis drug-induced hepatotoxicity (ATDH) causes substantial morbidity and mortality and diminishes treatment effectiveness. The incidence of ATDH during standard multidrug TB treatment has been ...

Methicillin-resistant S. aureus (MRSA) remains the leading cause of bacterial infections worldwide with a dwindling repertoire of effective antimicrobials active against it. This review aims to provide an update on novel ...

Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl ...

The histochemicallocalization of succinic de hydrogenases has been studied in the silk-glands of the various instars of Bombyx mori. The probable significance of the succinic dehydrogenase actiyity in the secretory metabolism ...

Pyran ring system is widely present in animal and plant kingdom and possesses diverse pharmacological activities. Pyran is a six-membered oxygen heterocycle with two double bonds. Out of five carbon atoms of pyran ring, ...

Stroke has been defined by the World Health Organisation as “a focal (or, at times, global) neurological impairment of sudden onset, and lasting more than 24 hours (or leading to death) and of presumed vascular origin”. ...

The drug discovery process mainly depends on the discovery of compounds that cure or help to treat diseases. One of the major goals in drug discovery research is to identify high affinity and specific ligands for receptors ...

Diabetes is a disease characterized by high levels of blood glucose resulting from defects in insulin production, insulin action or both. Type 2 diabetes is typically a polygenic disease that results from a complex interplay ...