Thrombosis is the leading cause of morbidity and mortality worldwide. Despite the existing anti-thrombotic treatment more than 15% of patients with acute coronary syndrome suffer from ischemic stroke. The present study was ...

Presently, population expansion is the growing matter of concern in the world. According to United States Census Bureau, the current estimation of global population is 6.93 billion. Furthermore, the poor family planning ...

Schizophrenia is the most devastating and enduring psychotic disorder affecting as many as 1% of the population worldwide, with a similar prevalence between the both genders, throughout diverse cultures and geographic ...

Highly fluorescent, stable blue, skyblue and green color light emitting teraryls and quateraryls were prepared from a ketene-S,S-acetal under mild conditions. These compounds exhibited photoluminescence both in solid state ...

Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence ...

A series of novel nucleoside analogues having dual bases (pyrimidine and triazole) and sugars have been synthesized by CuAAC reaction of azido sugars with propynylated pyrimidines. These compounds were evaluated for their ...

Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent with cancer cell-selective cell death inducing effect. However, the major limitation in the usage of TRAIL as a chemotherapeutic ...

Ulmus wallichiana (UW) is an endangered and folk medicinal plant used for healing fractures in India. Recently, the secondary metabolites isolated and identified from its bark revealed osteogenic activity. Considering the ...

We have designed and synthesized dissymmetrical diaryl 2-methylenepropylidenes based on pyrazolo[3,4-d]pyrimidine core for studying conformational control due to arene interactions in face-to-face (offset) mode. Dissymmetrical ...