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| Title: | Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents |
| Other Titles: | Corrigendum to ‘‘Combinatorial Synthesis and Biological Evaluation of Isoxazole-Based Libraries as Antithrombotic Agents’’ [Bioorg. Med. Chem. Lett. 12 (2002) 1905] |
| Authors: | Batra, Sanjay
Srinivasan, T
Rastogi, S K
Kundu, Bijoy
Patra, A
Bhaduri, A P
Dikshit, Madhu |
| Issue Date: | 2002 |
| Citation: | Bioorg. Med. Chem. Lett. 12, 1905-1908, Bioorganic & Medicinal Chemistry Letters 12 (2002) 3349 |
| Series/Report no.: | CDRI Communication no. 6071 |
| Abstract: | The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized isoxazole-based libraries comprising of 32, 96 and 45 compounds each have been synthesized in parallel format using Baylis Hillman reaction, Michael addition, reductive amination and alkylation reactions. With an objective of lead generation all the three libraries were evaluated for their antithrombin activity in vivo. |
| URI: | http://hdl.handle.net/123456789/80 |
| Appears in Collections: | Medicinal and Process Chemistry
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Files in This Item:
| File |
Description |
Size | Format |
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| sbatra-6071-BMCL-2002-12-1905.pdf | | 119Kb | Adobe PDF | View/Open | | corrigendsbatra-bmcl-12-1905.pdf | | 52Kb | Adobe PDF | View/Open |
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