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| Title: | REVERSIBLE SUPPRESSION OF NITRIC OXIDE SYSTEM IN ESSENTIAL HYPERTENSION |
| Authors: | Chandra, M
Maurya, D R
Kumar, S
Basara, H
Ghatak, Ashim
Tekwani, B L
Kaur, G
Misra, M K |
| Keywords: | Nitric oxide
Essential hypertension
Antihypertensive treatment
Antioxidants |
| Issue Date: | 2003 |
| Citation: | Indian Journal of Clinical Biochemistry, 2003, 18 (2) 150-153 |
| Abstract: | Despite enormous research in the field of hypertension, its pathophysiology still remains
largely unresolved and appears to be multifactorial. In the present communication, we have
analyzed the status of nitric oxide (NO) in the patients with essential hypertension and age
matched controls. We have found that the levels of NO are lowered in essential hypertension.
The normalization of blood pressure by administration of antihypertensive therapy causes rise
in the NO level indicating that perturbed NO status in essential hypertension is reversible.
Addition of antioxidant to the antihypertensive drugs causes a further, though non significant,
rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive
drugs as adjunct in the management of essential hypertension. |
| URI: | http://hdl.handle.net/123456789/78 |
| Appears in Collections: | Clinical & Experimental Medicine
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| aghatak-indjclinbiochem- 2003-18-150.pdf | | 98Kb | Adobe PDF | View/Open |
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