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| Title: | LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF CLADRIN AND EQUOL IN RAT PLASMA AND ITS APPLICATION IN PHARMACOKINETICS STUDY OF CLADRIN |
| Authors: | Lakshmi, Manickavasagam
Gupta, Sonal
Mishra, Smriti
Rakesh, Maurya
Naibedya, Chattopadhyay
Jain, G K |
| Keywords: | Cladrin
Equol
rat plasma
LC-MS/MS |
| Issue Date: | 2010 |
| Citation: | Medicinal Chemistry Research, 19.1), S79-S79 |
| Series/Report no.: | CDRI COMMUNICATION NO. 7956 |
| Abstract: | A rapid and selective LC-MS/MS method for simultaneous analysis of cladrin and equol in female rat plasma has been developed and validated. The chromatographic separation was carried out on RP18 column and MS/MS analysis was performed in triple quadrupole mass spectrometer with electrospray ionization (ESI). The method was linear for the concentration range from 7.8ng/ml to 1000ng/ml for cladrin and 3.9ng/ml to 1000ng/ml for equol. The intra-day and inter-day accuracy and precision of the method were within the acceptable limits. The validated LC-MS/MS method was successfully applied for the pharmacokinetics study of cladrin at 10mg/kg in female S.D. rats. |
| URI: | http://hdl.handle.net/123456789/729 |
| Appears in Collections: | Pharmacokinetics & Metabolism
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Files in This Item:
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Description |
Size | Format |
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| 7956-32-10-Medicinal Chemistry Research, 19(suppl.1), S79-S79.pdf | | 82Kb | Adobe PDF | View/Open |
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