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| Title: | A Facile synthesis of 3-Methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] di-azepin-2-ones and 3-arylemethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines |
| Authors: | Pathak, Richa
Nag, Somnath
Batra, Sanjay |
| Keywords: | Baylis-Hillman
1,2-phenylenediamine
3-Methylene-4-aryl-1
3,4,5-tetrahydro-benzo[b][1,4] diazepin-2-ones
3-arylmethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines. |
| Issue Date: | 2006 |
| Citation: | Synthesis (2006), 4205-4211 |
| Series/Report no.: | CDRI Communication No. 7050. |
| Abstract: | A simple and convenient synthesis of 3-methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] diazepin-2-ones was accomplished by the SN2 nucleophilic substitution of the acetates of Baylis-Hillman adducts of acrylate with 1,2-phenylenediamines followed by base-mediated intramolecular cyclization. On the other hand similar substrates derived from the Baylis-Hillman adducts of acrylonitrile via Pinner’s reaction leads to 3-arylmethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines in good yields.. |
| URI: | http://hdl.handle.net/123456789/71 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-7050-SYNTHESIS-2006-4205.pdf | | 144Kb | Adobe PDF | View/Open |
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