Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India): Item 123456789/610

	Home

Browse
	Communities & Collections
	Titles
	Authors
	By Date

Sign on to:
	Receive email updates
	My DSpace authorized users
	Edit Profile

CDRI Website
CDRI Mail


	About DSpace

Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India) >
Publications of CDRI Scientists >
Endocrinology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/610

Title:	Breast Cancer Risk Associated with Polymorphisms of IL-1RN and IL-4 Gene in Indian Women
Authors:	Konwar, Rituraj Chaudhary, Preeti Kumar, Sandeep Mishra, Deepti Chattopadhyay, Naibedya Bid, H K
Keywords:	breast cancer IL-1RN IL-4 polymorphism
Issue Date:	2009
Citation:	Oncol Res. 2009, 17(8), 367-72
Abstract:	BACKGROUND: Interleukins and cytokines are important regulator of the aetio-pathogenesis of majority of cancers. Mechanistic role of IL-1RN and IL-4 particularly in breast carcinogenesis is well documented. However, the role of polymorphisms of IL-1RN and IL-4 combinations associated with risk of breast cancer not reported. METHODS: The IL-1RN and IL-4 gene polymorphism were genotyped with VNTR-PCR in 100 patients (benign tumor, n=32 and breast cancer, n=68) and 200 normal healthy control subjects with normal mammogram. Genotype distribution and allelic frequencies between patients and controls were compared and odds ratio (ORs) with 95% confidence intervals (CI) were calculated using SPSS software (version-12.0) RESULTS: There were no significant differences in the genotype distributions of both IL-1RN and IL-4 polymorphisms between cases and controls. Similarly, subgroup analysis showed that there is no significant association for pre and postmenopausal women. However, BB genotype of IL-1RN is significantly differs among benign and malignant stages of breast cancer. CONCLUSIONS: IL-1RN and IL-4 polymorphism alone or in combination are not associated with risk of breast cancer in Indian patients. The association of IL-1RN with malignant stages may indicate its possible role in progression of breast cancer. Further studies in other population are needed to confirm our findings and to elucidate the role of IL-1RN in progression of breast cancer.
URI:	http://hdl.handle.net/123456789/610
Appears in Collections:	Endocrinology

Files in This Item:

File	Description	Size	Format
Riturajkonwar-7530-Oncol Res.-2009-17(8)-367-72.pdf		117Kb	Adobe PDF	View/Open

DKR - A Collaborative Effort of Documentation & Library Services Division and Information Technology Unit, CDRI, Lucknow
For Suggestions/Observations, Please mail to Suman K Mallik