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| Title: | Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents |
| Authors: | Sharma, Moni
Chaturvedi, Vinita
Manju, Y K
Bhatnagar, Shalini
Srivastava, Kumkum
Puri, S K
Chauhan, P M S |
| Keywords: | Tuberculosis
Malaria
Chalcones
Pyrimidines |
| Issue Date: | 2009 |
| Citation: | European Journal of Medicinal Chemistry , 44, 5, 2009, 2081-2091 |
| Abstract: | Frequency of tuberculosis and malaria is progressively increasing worldwide. New emerging strain of bacterium and resistance to currently available drugs make this field more conscientious and alarming. In this connection a series of substituted quinolinyl chalcones and substituted quinolinyl pyrimidines were synthesised and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV and antimalarial activity against NF-54 strain of Plasmodium falciparum. A comparison of structure-activity relationship reveals that different physicochemical and structural requirements exist for these two activities. Out of synthesized compounds, compound No. 18, 19 have shown antitubercular activity of MIC 3.12 µg/ml and were non toxic against VERO, MBMDM cell lines and compounds 49, 50, 51 have shown antimalarial activity of MIC 1.0 µg/ml. |
| URI: | http://hdl.handle.net/123456789/579 |
| Appears in Collections: | Medicinal and Process Chemistry
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| chauhanpms-7510-EJMC-44-5-2009-2081-2091.pdf | | 178Kb | Adobe PDF | View/Open |
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