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http://hdl.handle.net/123456789/577
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| Title: | Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials |
| Authors: | Sunduru, Naresh
Srivastava, Kumkum
Rajakumar, S
Puri, S K
Saxena, J K
Chauhan, P M S |
| Keywords: | 4-aminoquinolines
antimalarial
P. falciparum
P. yoelii
Thiazolidinedione
Thiazolidinedione
Thioparabanic acid |
| Issue Date: | 2009 |
| Citation: | Bioorganic & Medicinal Chemistry Letters 19(9), 2009, 2570-2573 |
| Abstract: | In search of new 4-aminoquinolines which are not recognized by CQR mechanism, thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activity. Thiourea derivative 3 found to be the most active against CQ sensitive strain 3D7 of P. falciparum in an in vitro model with an IC50 of 6.07 ng/mL and also showed in vivo suppression of 99.27% on day 4 against CQ resistant strain N-67 of P. yoelii. |
| URI: | http://hdl.handle.net/123456789/577 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Chauhanpms-7684-BMCL-19-9-2009-2570-2573.pdf | | 121Kb | Adobe PDF | View/Open |
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