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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/570
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| Title: | Agents Acting on the Central Nervous System: Part IX - S,6-Disubstituted6,7,8,9-Tetrahydro-sH-benzocyc1oheptenes& 8,9-Dihydro-7 H-benzocyc1oheptadiene |
| Authors: | KHANNA, JM
ANAND, NITYA |
| Keywords: | Heptenols
NMR studies
benzocyclohepten
transisomers |
| Issue Date: | 1968 |
| Citation: | Indian Journal of Chemistry, 6,1968,6 |
| Abstract: | A series of 6-tertiaryamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ones and their corresponding
heptenols, 8,9-dihydro-7H-benzocyloheptadiene[6,5-d]pyrazoles, and isoxazoles has
been prepared and tested for their pharmacological activity. It has been shown that in reduction
of 6-tertiaryamino-6,7,8;9-tetrahydro-5H-benzocyclohepten-5-.ones both the cis- and transisomers
are formed, the structure of which have been assigned on the basis of NMR studies.
6-(4-N-methylpiperazinyl) -6,7,8,9-tetrahydro-5H -benzocyclohepten-5-one has been found to
possess marked adrenolytic activity, while 6-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-
5-one and the corresponding heptenol shows central depressant action. |
| URI: | http://hdl.handle.net/123456789/570 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Indian Journal of Chemistry- 6-1968-6.pdf | | 3696Kb | Adobe PDF | View/Open |
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