Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India) >
Publications of CDRI Scientists >
Medicinal and Process Chemistry >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/557
|
| Title: | Synthesis of [l-Isoleucine-, 3-Proline-, and 5-Alanine ]-angiotensins 11 |
| Authors: | Khosla, M C
Chaturvedi, N C
Smeby, R R
Bumpus, F M |
| Keywords: | 1-Isoleucine
dicyclohexylcarbodiimide
N-ethyl-5-phenylisoxazolium-3-sulfonate
angiotensin |
| Issue Date: | 1968 |
| Citation: | Biochemistry, 7,1968,3417 |
| Abstract: | 1-Isoleucine,5-isoleucine]-angiotensin II and
[3-proline,5-isoleucine]-angiotensin II were synthesized by the solid-phase method using dicyclohexylcarbodiimide as the condensing agent. The formation of the arginyl-proline bond was extremely difficult under conditions
used. The former had about 25% pressor and
50% oxytocic activities giving further evidence the acidity of the j3-carboxyl is unnecessary. The latter possessed 40% pressor and 80% oxytocic activities of
the parent angiotensin. This relatively high biological activity was surprising because of the limitation on possible peptide conformations imposed by this cyclic
amino acid. [5-Alanine]-angiotensin II was prepared by solid phase using N-ethyl-5-phenylisoxazolium-3-sulfonate as the condensing agent. This peptide possessed
approximately 5% of pressor activity of angiotensin II indicating the importance of branched side chain of valine or isoleucine occurring naturally in this position. |
| URI: | http://hdl.handle.net/123456789/557 |
| Appears in Collections: | Medicinal and Process Chemistry
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| American Chem. Society-7-1968-3417.pdf | | 3927Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
