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| Title: | Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones. |
| Authors: | GUPTA, C M
BHADURI, A P
KHANNA, K M |
| Keywords: | CNS depressants
sodium hydroxide
2-Substituted
2,3-disubstituted |
| Issue Date: | 1968 |
| Citation: | Indian journal of chemistry,6,1968,621,623. |
| Abstract: | A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7) quinazolin-4-one with hydrazine, phenylhydrazine, and primary and secondary amines. The 2,3-disubstituted derivatives have been obtained by the reaction of 2-mercapto-3-phenyl-benzo(6,7)quinazoline-
4-one with appropriate alkyl, arylalkyl, dialkylamino-alkyl halides in the presence of alcoholic sodium hydroxide. Some of the compounds exhibit CNS-depressant activity at high dosage. |
| URI: | http://hdl.handle.net/123456789/553 |
| Appears in Collections: | Medicinal and Process Chemistry
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| IJOC-6-1968-621-623.pdf | | 1941Kb | Adobe PDF | View/Open |
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