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http://hdl.handle.net/123456789/521
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| Title: | Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline-2-ones |
| Authors: | Mishra, Amita
Batra, Sanjay |
| Keywords: | Quinazoline
Anagrelide
Baylis-Hillman
imidazo[2,1-b]quinazoline
allyl amine |
| Issue Date: | 2009 |
| Citation: | Synthesis 2009, no. 18, 3077-88 |
| Series/Report no.: | CDRI Communication Number 7780 |
| Abstract: | A facile method for the synthesis of 2-amino-3,4-dihydroquinazolines from the Baylis-Hillman derivatives has been disclosed. The protocol involves the sequential SN2-reaction of a primary amine on the Baylis-Hillman acetate of 2-nitrobenzaldehyde, CNBr-mediated nitrile addition and Fe-AcOH-promoted reductive cyclization. The approach has been extended for constructing imidazo[2,1-b]quinazoline-2-ones and imi-dazo[2,1-b]qinazolines in one pot. |
| URI: | http://hdl.handle.net/123456789/521 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-7780-Synthesis-2009-3077.pdf | | 267Kb | Adobe PDF | View/Open |
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