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| Title: | Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines |
| Authors: | Mishra, A
Srivastava, K
Tripathi, R
Puri, S K
Batra, Sanjay |
| Keywords: | antimalarial
thioureido quinazolines
chloroquine
P. falciparum
P. yoelii nigeriensis |
| Issue Date: | 2009 |
| Citation: | European Journal of Medicinal Chemistry (2009), 44 (11), 4404-4412 |
| Series/Report no.: | CDRI Communication Number 7714 |
| Abstract: | Syntheses and in vitro antimalarial evaluation of 42 new thioureido quinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 strain of P. falciparum whereas one of the compounds shows 50% curative effect in the mouse model at an oral dose of 100mg/kg x 4 days against multi drug resistant P. yoelii nigeriensis |
| URI: | http://hdl.handle.net/123456789/520 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-7714-EJMC-2009-44-4404.pdf | | 141Kb | Adobe PDF | View/Open |
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