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http://hdl.handle.net/123456789/513
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| Title: | A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis-Hillman adducts |
| Authors: | Nag, Somnath
Mishra, Amita
Batra, Sanjay |
| Keywords: | Baylis-Hillman
Allyl amine
BrCN, pyrimido[2,1-b]quinazoline
In
intramolecular cyclization |
| Issue Date: | 2008 |
| Citation: | Tetrahedron 64 (2008) 10162–10171 |
| Series/Report no.: | CDRI Communication No 7563 |
| Abstract: | A highly simplified approach for the generation of substituted pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from the Baylis-Hillman adducts is described. Sequential reductive alkylation of the primary allyl amine with 2-nitrobenzaldehyde, reduction of the aromatic nitro group with In, CNBr-promoted intramolecular cyclization followed by NaOMe-mediated another intramolecular cyclization furnish the title compounds. |
| URI: | http://hdl.handle.net/123456789/513 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sanjaybatra-7563-2008-tetrahedron-64-10162.pdf | | 253Kb | Adobe PDF | View/Open |
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