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| Title: | Comparison of the Effect of Compound CDRI 80/53 [N-(3-acetyl-4,5-dihydro-2-furanyl)-N4-(6 -methoxy-8-quinolinyl)1,4- pentanediamine] with Primaquine on Human Erythrocytes In Vitro |
| Authors: | Anklesaria, P S
Ashar, V J
Kshirsagar, N A
Gupta, K C |
| Issue Date: | 1994 |
| Citation: | Tropical diseases: molecular biology & control strategies,1994,256-261 |
| Abstract: | Comparative in vitro study of a malaria antirelapse compound CDRI Code
80/53 with primaquine (PQ) was done on the erythrocytes of eight normal and six G-6-PD-deficient individuals. Reduced glutathione (GSH) was estimated in the RBCs exposed to the in vitro action of the drugs. Statistically significant decreases were observed at 25 ug/ml and 50 ยต/ml doses of PQ as compared t the equivalent doses of compound 80/53 in both normal and G-6-PD-deficient erythrocytes. The study showed that compound CDRI 80/53 did not damage normal as well as G-6-PD-deficient erythrocytes to the same extent as PQ. |
| URI: | http://hdl.handle.net/123456789/505 |
| Appears in Collections: | Microbiology
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| book-tropical diseases molecular biology & control stategies-1994-286.pdf | | 1350Kb | Adobe PDF | View/Open |
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