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| Title: | Causal prophylactic activity of a new 8-aminoquinoline derivative against plasmodium cynomolgi B in rhesus monkeys |
| Authors: | Puri, S K
Dutta, G P |
| Issue Date: | 1990 |
| Citation: | Indian J Med Research (1990) 91,197-199 |
| Abstract: | A new 8-aminoquinoline derivative, N'-(3-acetyl-4-5-dihydro-2 furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine, synthesized at CDRI, Lucknow, showed causal prophylactic activity at 3.16mg/kg x3 doses (on day -1,0 and+1)against sporozoite induced P.cynomelgi B infection in rhesus monkeys. Single dose of IOmg/kg of this compound on day 0 also prevented establishment of patent infection. Activity of the compound was comparable to that of primaquine (with causal prophylactic activity at 1.78mg/kg in three day test and at 10.0mg/kg in single dose test). |
| URI: | http://hdl.handle.net/123456789/503 |
| Appears in Collections: | Microbiology
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| indianjmedresA-91-1990-197-199.PDF | | 1784Kb | Adobe PDF | View/Open |
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