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| Title: | Effect of a new 8-aminoquincline antimalarial compound on hepatic microsomal mixed function oxidase system of mice |
| Authors: | Saxena, Nalini
Pandev, V C
Puri, S K
Dutta, G P |
| Issue Date: | 1989 |
| Citation: | Indian J Med Res 89,1989, 330-333 |
| Abstract: | A new 8-aininoquhmline derivative (compound 80/53) synthesized at the Central Drug Research Institute, Lucknow (India), has been found to be an active anti-relapse (tissue schizontocidal) compound. Compound 80/53 at 8.75 mg/kg x 4 days and primaquine at 7.00 mg/`kg (base) 4 days given orally to Swiss mice led to inhibition of the different components of the hepatic microsomal mixed function oxidase system to varying degrees. Compound 80/53 inhibited cytochrome P-450, aminopyrin-N-demethylase, aniline and benzo (a) pyrene hydroxyslase, cytochrome b5 and heme content of the normal mice by 12, 14, 0, 57, 20 and 6 per cent respectively, whereas the inhibition caused by primaquine in these components was 25, 21, 17, 48, 26 and 6 per cent respectively. Thus, there was less inhibition of hepatic microsomal MFO system of mice by compound 80/53 as compared to that by primaquine, |
| URI: | http://hdl.handle.net/123456789/500 |
| Appears in Collections: | Microbiology
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| indianjofmedres-89-330-333-1989.pdf | | 1566Kb | Adobe PDF | View/Open |
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