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http://hdl.handle.net/123456789/488
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| Title: | Synthesis and antitubercular screening of imidazole derivatives |
| Authors: | Pandey, Jyoti
Tiwari, Vinod K
Verma, Shyam S
Chaturvedi, Vinita
Bhatnagar, Shalini
Sinha, Sudhir
Gaikwad, A N
Tripathi, R P |
| Keywords: | Tuberculosis
Imidazoles
Glycosyl amino ester
C-allylation |
| Issue Date: | 2009 |
| Citation: | European Journal of Medicinal Chemistry(2009),44, 3350–3355 |
| Series/Report no.: | CDRI Communication No. 7398 |
| Abstract: | A series of imidazole based compounds were synthesized by reacting simple imidazoles either with alkyl halides in presence of tetrabutylammonium bromide (TBAB) or by conjugate addition of imidazoles to ethyl acrylate or glycosyl olefinic ester. The synthesized compounds were screened against M. tuberculosis where compound 17 exhibited good in vitro antitubercular activity that may serve as a lead for further optimization. |
| URI: | http://hdl.handle.net/123456789/488 |
| Appears in Collections: | Medicinal and Process Chemistry
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| European Journal of Medicinal Chemistry 44 _2009_ 3350–3355.pdf | | 157Kb | Adobe PDF | View/Open |
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