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http://hdl.handle.net/123456789/485
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| Title: | 5, 6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents |
| Authors: | Singh, Fateh V
Parihar, Amrita
Chaurasia, Sumit
Singh, Amar B
Singh, Salil P
Tamrakar, Akhilesh K
Srivastava, Arvind K
Goel, Atul |
| Issue Date: | 2009 |
| Citation: | Bioorg. Med. Chem. Lett.(2009) 19, 2158-2161 |
| Series/Report no.: | CDRI communication number 7335 |
| Abstract: | Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC50 values of 58-72 alphaM. Three of the test compounds showed significant (25-37%) lowering of plasma glucose level at 24 h in sucrose-challenged streptozotocin-induced diabetic Sprangue-Dawley rat model. |
| URI: | http://hdl.handle.net/123456789/485 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Bioorg. Med. Chem. Lett. 2009,19, 2158-2161.pdf | | 161Kb | Adobe PDF | View/Open |
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