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| Title: | Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials |
| Authors: | Misra, Mridul
Pandey, Swaroop Kumar
Pandey, Vivek Parashar
Pandey, Jyoti
Tripathi, Renu
Tripathi, R P |
| Keywords: | Tetrahydropyridines
Antimalarial activity
L-proline
Organocatalysis
Schizont maturation
Trifluoroacetic acid |
| Issue Date: | 2009 |
| Citation: | Bioorganic & Medicinal Chemistry(2009),17,625–633 |
| Series/Report no.: | CDRI communication No.7466 |
| Abstract: | A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against P. falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 µg /mL. |
| URI: | http://hdl.handle.net/123456789/484 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Bioorganic & Medicinal Chemistry 17 _2009_ 625–633.pdf | | 209Kb | Adobe PDF | View/Open |
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