Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India) >
Publications of CDRI Scientists >
Medicinal and Process Chemistry >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/481
|
| Title: | A facile synthesis of α, α´-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations |
| Authors: | Singh, Nimisha
Pandey, Jyoti
Yadav, Amit
Chaturvedi, Vinita
Bhatnagar, Shalini
Gaikwad, Anil N
Sinha, Sudhir Kumar
Kumar, Awaneet
Shukla, P K
Tripathi, R P |
| Keywords: | α, α′-(EE)-bis(benzylidene)-cycloalkanones
Antifungal
Antitubercular |
| Issue Date: | 2009 |
| Citation: | European Journal of Medicinal Chemistry(2009), 44, 1705–1709 |
| Series/Report no.: | CDRI Communication No. 7369 |
| Abstract: | An economical and facile synthesis of α, α′-(EE)-bis(benzylidene)-cycloalkanones was achieved by reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the selected compounds were reduced with NaBH4 to the respective α, α′-(EE)-bis(benzylidene)-cycloalkanols. All these compounds and our earlier synthesized cyclohexyl phenyl methanols were evaluated for their antitubercular, antifungal and antibacterial activities. Several compounds displayed moderate antitubercular activity with MIC 12.5-1.56 μg/mL. However, none of the compounds displayed any significant antifungal activity. |
| URI: | http://hdl.handle.net/123456789/481 |
| Appears in Collections: | Medicinal and Process Chemistry
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| European Journal of Medicinal Chemistry 44 _2009_ 1705–1709.pdf | | 190Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
