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| Title: | Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans |
| Authors: | Dixit, Manish
Saeed, Uzma
Kumar, Amit
Siddiqi, Mohammad Imran
Tamraka, Akhilesh K
Srivastava, Arvind K
Goel, Atul |
| Keywords: | Diabetes
PTP1B
4,5-dihydronaphthofuran
dibenzofuran
molecular docking |
| Issue Date: | 2008 |
| Citation: | Med. Chem.(2008), 4, 18-24 |
| Series/Report no.: | CDRI Communication No. 7051 |
| Abstract: | Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity. |
| URI: | http://hdl.handle.net/123456789/480 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Med. Chem. 2008, 4, 18-24.pdf | | 171Kb | Adobe PDF | View/Open |
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