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| Title: | Interesting results of catalytic hydrogenation of 3-(2-nitrophenyl)-isoxazoles and 3-(nitro-substituted-phenyl)-2-isoxazolines |
| Authors: | Singh, Vijay
Madapa, Sudharshan
Yadav, G P
Maulik, Prakas R
Batra, Sanjay |
| Keywords: | Isoxazole
2-isoxazoline
4-aminoquinoline
hydrogenation
Pd-C
ring transformation
regiospecific |
| Issue Date: | 2006 |
| Citation: | Syntheis, (2006), 1995-2004 |
| Series/Report no.: | CDRI Communication no 6402 |
| Abstract: | The Pd-C-assisted hydrogenolysis of substituted 3-(2-nitrophenyl)-isoxazoles, irrespective of substitution on the isoxa-zole ring, invariably leads to reduction of nitro to amino group with concomitant regiospecific ring closure to yield substituted 4-quinolinamines. In contrast similar hydrogenation of 3-(nitro substituted phenyl)-2-isoxazolines results in reduction of the nitro group only with conservation of isoxazoline ring to yield 3-(amino substituted phenyl)-2-isoxazolines. |
| URI: | http://hdl.handle.net/123456789/42 |
| Appears in Collections: | Medicinal and Process Chemistry
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| 6402-SYNTHESIS-2006-1995.pdf | | 247Kb | Adobe PDF | View/Open |
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