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| Title: | Convenient synthesis of substituted α-methylene--valerolactones in aqueous medium using Baylis-Hillman chemistry |
| Authors: | Singh, Vijay
Batra, Sanjay |
| Keywords: | Baylis-Hillman
α-methylene--valerolactone
nucleophilic substitution
aqueous medium |
| Issue Date: | 2006 |
| Citation: | Synthesis ( 2006), 63-72 |
| Series/Report no.: | (1) CDRI Communication No. 6732 |
| Abstract: | A mild and convenient synthesis of substituted α-methylene--valerolactones was achieved by SN2 nucleophilic substitution of the acetates of the Baylis-Hillman adducts with acetyl acetone followed by one-pot saponification of the ester, reduction of the keto group and subsequent intramolecular ring closure in aqueous medium. |
| URI: | http://hdl.handle.net/123456789/36 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-6732-Synthesis-2006-63.pdf | | 287Kb | Adobe PDF | View/Open |
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