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| Title: | Expeditious synthesis of 5,6,7 ,8-tetrahydro-imidazo[1,2-a ] pyrimidin-2-ones and 3,4,6,7 ,8,9-hexahydro-pyrimido[,2-a ] pyrimidin-2-ones |
| Authors: | Pathak, Richa
Batra, Sanjay |
| Issue Date: | 2007 |
| Citation: | Tetrahedron 63 (2007) 9448-9455 |
| Series/Report no.: | CDRI communication no. 7163 |
| Abstract: | A convenient synthesis of new 5,6,7 ,8-tetrahydro-imidazo[ 1,2-a]pyrimidin-2-ones and 3,4,6,7 ,8,9-hexahydro-pyrimido[1 ,2a]pyrimidin-2-
ones from the Baylis-Hillman adducts of acrylonitrile and their derivatives is described. A common strategy employed to achieve the syntheses of title
compounds involved generation of diamines from different Baylis-Hillman derivatives followed by treatment with cyanogen bromide at reflux
temperature to trigger a double intramolecular cyclization. |
| URI: | http://hdl.handle.net/123456789/35 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-tet-63-9448.pdf | | 184Kb | Adobe PDF | View/Open |
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