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| Title: | Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents |
| Authors: | Batra, Sanjay
Roy, Amrendra K
Patra, A
Bhaduri, A P
Surin, W R
Raghavan, S A V
Sharma, P
Kapoor, Kapil
Dikshit, Madhu |
| Keywords: | Baylis-Hillman reaction
Isoxazolecarbaldehyde
isoxazole
nucleophilic substitution
substituted piperazine
antithrombotic activity
platelet aggregation |
| Issue Date: | 2004 |
| Citation: | Bioorg. Med. Chem., 12(9), 2059-2077 |
| Series/Report no.: | CDRI Communication No. 6468 |
| Abstract: | The solution phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented. |
| URI: | http://hdl.handle.net/123456789/34 |
| Appears in Collections: | Medicinal and Process Chemistry
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| sbatra-6468-BMC-12-2059.pdf | | 293Kb | Adobe PDF | View/Open |
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