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| Title: | Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents |
| Authors: | Singh, B K
Mishra, Mridul
Saxena, Nisha
Yadav, G P
Maulik, P R
Sahoo, M K
Gaur, R L
Murthy, P K
Tripathi, R P |
| Keywords: | Dihydropyrimidines
1,4-dihdyropyrimidines
antifilarial
Brugia malayi
tetrabutylammonium bromide |
| Issue Date: | 2008 |
| Citation: | European Journal of Medicinal Chemistry 43, 2717-2723.(2008) |
| Series/Report no.: | CDRI Communication No. 7347 |
| Abstract: | A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8-21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl ester (2-7) with different alkyl or aralkyl halides in presence of a combination of anhydrous K2CO3 and catalytic amount of tetrabutyl ammonium bromide. The title compounds were evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro and in vivo at various concentrations. One of the compounds (18) showed promising antifilarial activity. |
| URI: | http://hdl.handle.net/123456789/322 |
| Appears in Collections: | Medicinal and Process Chemistry
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| rptripathi-2008-eurjouofmedchem-43-2717-2723.pdf | | 111Kb | Adobe PDF | View/Open |
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