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| Title: | Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential |
| Authors: | Verma, Shyam Sunder
Mishra, Ram Chandra
Tamrakar, Akhilesh Kumar
Tripathi, Brajendra Kumar
Srivastava, Arvind Kumar
Tripathi, R P |
| Issue Date: | 2004 |
| Citation: | J. Carbohydr. Chem. 23, 493.( 2004) |
| Series/Report no.: | CDRI Communication No. 6605 |
| Abstract: | Reductive amination of glycosyl aldehydes (1a-1c, 2) with glycosyl amino esters (3a-3c, 4) in presence of sodium borohydride gave diglycosylated amino esters (5-15) in good yields. N-Glycosyl-glycosylated amino esters were reduced to the respective diglycosyl amino alcohols (16-26) with LiAlH4 in good yierlds. All the synthesized compounds were studied for their inhibitory effect, if any, against hepatic glucose-6-phosphatase, glycogen phosphorylase and intestinal brush border membrane -glucosidase, among these compounds 7, 21 and 25 have shown marked inhibition on these enzymes, respectively. |
| URI: | http://hdl.handle.net/123456789/316 |
| Appears in Collections: | Medicinal and Process Chemistry
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| rptripathi-jcarbochem-2004-23-493.pdf | | 242Kb | Adobe PDF | View/Open |
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