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| Title: | Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction |
| Authors: | Pandey, Jyoti
Dwivedi, Namrata
Srivastava, A K
Tamarkar, A
Tripathi, R P |
| Issue Date: | 2007 |
| Citation: | Bioorganic & Med. Chem. Letters 17, 1321 (2007) |
| Series/Report no.: | CDRI Communication No 7057 |
| Abstract: | 1,3-Dipolar cycloaddition of azomethine ylides and glycosyl E-olefins in presence of LDA led to diastereoselective formation of C-glycosylated proline esters. The selected esters on regioselective hydrolysis with LiOH gave C-glycosyl prolines. Few of the proline esters exhibited very good α-glucosidase inhibitory activity. The organocatalytic activity of one of the prolines in a prototype Aldol reaction has also been established. |
| URI: | http://hdl.handle.net/123456789/308 |
| Appears in Collections: | Medicinal and Process Chemistry
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| rptripathi-Bioorganic & Med. Chem. Letters, 2007-17-1321.pdf | | 162Kb | Adobe PDF | View/Open |
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