Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India) >
Publications of CDRI Scientists >
Medicinal and Process Chemistry >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/277
|
| Title: | An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents |
| Authors: | Dwivedi, Namrata
Tewari, Neetu
Tiwari, V K
Chaturvedi, Vinita
Manju, Y K
Srivastava, A
Giakwad, A
Sinha, S
Tripathi, R P |
| Keywords: | Tuberculosis
Tetrabutylammonium bromide
Phenyl cyclopropyl methanones
Wolf- Kishner reduction |
| Issue Date: | 2005 |
| Citation: | Bioorg Med Chem Lett.15, 4526-30 (2005) |
| Abstract: | An efficient, high yield and one pot synthesis of phenyl cyclopropyl methanones on reaction of different aryl alcohols with 4’-fluoro-4-chloro-butyrophenone in THF/DMF in presence of NaH /TBAB is reported. All the compounds were evaluated for their antitubercular activities against M. tuberculosis H37 Rv in vitro displaying MICs ranging from 25-3.125 mcg/ml. The most active compounds showed activity against MDR strains and one of them showed marginal enhancement MST in mice. |
| URI: | http://hdl.handle.net/123456789/277 |
| Appears in Collections: | Medicinal and Process Chemistry
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| rptripathi-2005-BioMedChemLett-15-4526.pdf | | 139Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
