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| Title: | An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid |
| Authors: | Singh, Biswajit K
Bisht, Surendra Singh
Tripathi, R P |
| Keywords: | Ascorbic acid
DBU
Tetramic acid
Wittig Reaction
Pyridinium chlorochromate |
| Issue Date: | 2006 |
| Citation: | Beilstein J. Org. Chem.- Art No. 24 (2006) |
| Series/Report no.: | CDRI Communication No.7040 |
| Abstract: | A straightforward synthesis of tetramic acid derivatives with dienyl susbstituents at C-5 from L-ascorbic acid is reported. The synthesis involves the PCC oxidation of allylic alcohol followed by olefination and subsequent reaction with different amines to give 5-hydroxy lactams, which underwent pTSA catalysed dehydration to give the required tetramic acid derivatives. |
| URI: | http://hdl.handle.net/123456789/275 |
| Appears in Collections: | Medicinal and Process Chemistry
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| Beilstein J. Org. Chem., 2006, Art. No. 24.pdf | | 190Kb | Adobe PDF | View/Open |
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