Digital Knowledge Repository of Central Drug Research Institute, Lucknow (India) >
Publications of CDRI Scientists >
Molecular & Structural Biology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/240
|
| Title: | Tuftsin-Bearing Liposomes as Antibiotic Carriers in Treatment of Macrophage Infections |
| Authors: | Gupta, C M
Haq, W |
| Issue Date: | 2005 |
| Citation: | Methods Enzymol.391,291-304 (2005) |
| Abstract: | Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg)that specifically binds monocytes, macrophages, and polymorphonuclear leukocytes and potentiates their natural killer activity against tumors and pathogens. The antimicrobial activity of this peptide is significantly increased by attaching at the C-terminus a fatty acyl residue through the ethylenediamine spacer arm. This activity is further augmented by incorporating the modified tuftsin in the liposomes. The tuftsin-bearing liposomes not only enhance the host's resistance against a variety of infections but also serve as useful vehicles for the site-specific delivery of drugs in a variety of macrophage-based infections, such as tuberculosis and leishmaniasis. |
| URI: | http://hdl.handle.net/123456789/240 |
| Appears in Collections: | Molecular & Structural Biology
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| cmg--2005-methodsenzymol-391-291-304.pdf | | 4784Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
