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http://hdl.handle.net/123456789/126
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| Title: | Antibody-mediated targeting of liposomes to red cells in vivo |
| Authors: | Singhal, Arun
Gupta, C M |
| Keywords: | Drug targeting
Liposome
Cell-specific antibody
F( ab') 2 fragment
Erythrocyte |
| Issue Date: | 1986 |
| Citation: | FEBS Letters (1986), 201, 321-326 |
| Series/Report no.: | CDRI Communication No. 3847 |
| Abstract: | Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat
erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound
liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time
of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time
that liposomes can be successfully targeted to cells other than liver cells in vivo. |
| URI: | http://hdl.handle.net/123456789/126 |
| Appears in Collections: | Molecular & Structural Biology
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Files in This Item:
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Size | Format |
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| cmg-FEBSLetters-1986-201-321.pdf | | 2260Kb | Adobe PDF | View/Open |
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