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| Title: | Enhancement in anti-Semliki Forest virus activity of ds RNA by a muramyl dipeptide |
| Authors: | George, C X
Jain, Rakesh K
Gupta, C M
Anand, Nitya |
| Keywords: | Viral infection
Interferon inducer
Muramyl dipeptide
Macrophage activation |
| Issue Date: | 1986 |
| Citation: | FEBS Letters (1985), 200, 37-41 |
| Series/Report no.: | CDRI Communication No.3790 |
| Abstract: | Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP-induced increase in nonspecific resistance to infection. These results indicate that a combined
treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections. |
| URI: | http://hdl.handle.net/123456789/125 |
| Appears in Collections: | Molecular & Structural Biology
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| cmg-FEBSLetters-1986-200-37.pdf | | 1667Kb | Adobe PDF | View/Open |
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