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| Title: | Synthesis of Carbamyl and Ether Analogs of Phosphatldylchollnes |
| Authors: | Agarwal, Kirti
Bali, Anu
Gupta, C M |
| Keywords: | liposome
drug delivery
plasma lipoprotein
phosphatidyl analog
phospholipases |
| Issue Date: | 1984 |
| Citation: | Chemistry and Physics of Lipids (1984), 36, 169-177 |
| Series/Report no.: | CDRI Communication No. 3539 |
| Abstract: | A complete synthesis of I-O-hexadecyl-2-O-N-(heptadec-8-cis-enyl)carbamyl-sn-glycer0-3-
phosphocholine. a novel analog of phosphatidylcholine, has been described. Each step is simple to perform and gives the desired products in high yield. Also, some of the intermediates formed during the synthesis have been efficiently utilized to prepare 1-O-hexadecyl-2-O-oleyl-snglycero-
3-phosphocholine, I-O-hexadecyl-2-oleoyl-sll-glycero-3-phosphocholine and 3-O-hexadecyl-2-oleoyl-sn-glycero-l-phosphocholine. These phosphatidy1choline (PC) analogs are useful for studying the possible role of phospholipases in the capture and lysis of liposomes in vivo. |
| URI: | http://hdl.handle.net/123456789/122 |
| Appears in Collections: | Molecular & Structural Biology
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| cmg-1984-chemphyslipids-36-169.pdf | | 2196Kb | Adobe PDF | View/Open |
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