http://dkr.cdri.res.in:8080/xmlui/handle/123456789/1177 2026-04-19T12:11:02Z http://dkr.cdri.res.in:8080/xmlui/handle/1/1751 Synthesis of Oligosaccharides Related to Bacterial Cell Wall Polysacchairdas Steroidal Glycosides and Blood Group Antigens Karki, Geeta; Mandal, Pintu Kumar (Guide) from the Greek word saccharon meaning sugar.3 Carbohydrates that cannot be hydrolyzed into simpler compounds are called “monosaccharides” such as glucose, fructose etc. and a carbohydrate that can be hydrolyzed to two monosaccharides is called a disaccharide. e.g., sucrose, maltose, lactose, melibiose, cellobiose etc. while those composed of many monosaccharide units are called polysaccharides. Carbohydrates with an aldehydic group are known as “aldoses” and those with a ketonic functionality are “ketoses”. Depending upon the number of carbon atoms it contains, the monosaccharide is termed as tetrose, pentose, hexose and so on. Polysaccharides can also be classified4-6 into homopolysaccharide and heteropolysaccharide depending on the monosaccharide units present. The carbohydrates those containing only one type of monosaccharide units are called homopolysaccharides e.g. glucans, mannans, galactans, arabinans etc. whereas heteropolysaccharides contain two or more different monosaccharide units, e.g. glucomannans, galactomannans, arabinogalactans etc. Depending upon their functional property, polysaccharides can be divided into two parts. One is fibrous polysaccharide, e.g. cellulose in higher plants and some algae, chitin in yeast and fungi. The other one is the polysaccharide having matrix forming property and is characterized by their gel forming characteristics which confer flexibility on the structural assembly. Arabinoxylans, galactomannans of plant origin represent this group. Guide- Dr. Pintu Kumar Mandal. PhD Theses Submitted by to AcSIR,Ghaziabad UP in 2019 by Geeta Karki. 2019-04-16T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/1/1750 A STUDY ON NEUROINFLAMMATION AND ITS INFLUENCE ON NMDA RECEPTOR AND SYNAPTIC FUNCTION IN STZ (ICV) INDUCED MEMORY IMPAIRED RATS Rai, Shivika; Shukla, Rakesh (Guide) In the present study the role of glial activation and post synaptic toxicity in ICV Streptozotocin (STZ) induced memory impaired rats was explored. In experiment set up 1: Memory deficit was found in Morris water maze test on 14–16 days after STZ (ICV; 3 mg/Kg) administration. STZ causes increased expression of GFAP, CD11b and TNF-α indicating glial activation and neuroinflammation. STZ also significantly increased the level of ROS, nitrite, Ca2+ and reduced the mitochondrial activity in synaptosomal preparation illustrating free radical generation and excitotoxicity. Increased expression and activity of Caspase-3 was also observed in STZ treated rat which specify apoptotic cell death in hippocampus and cortex. STZ treatment showed decrease expression of post synaptic markers CaMKIIα and PSD-95, while, expression of pre synaptic markers (synaptophysin and SNAP-25) remains unaltered indicating selective post synaptic neurotoxicity. Oral treatment with Memantine (10 mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain. Further, in experiment set up 2: where memory function was not affected i.e. 7–9 days after STZ treatment. The level of GFAP, CD11b, TNF-α, ROS and nitrite levels were increased. On the other hand, apoptotic marker, synaptic markers, mitochondrial activity and Ca2+ levels remained unaffected. Collective data indicates that neuroinflammatory process and oxidative stress occurs earlier to apoptosis and does not affect memory function. Present study clearly suggests that glial activation and post synaptic neurotoxicity are the key factors in STZ induced memory impairment and neuronal cell death. Guide- Dr. Rakesh Shukla, PhD Theses Submitted by AcSIR,Ghaziabad UP by Shivika Rai 2015-08-26T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/1/1749 Development and evaluation of Inhalable particdes Containing kanamycin monosulhate and pyrazinoic acid for the treatment of drug resistant tuberculosis. Srivastava, Ashish; Misra, Amit (Guide) Tuberculosis (TB) remains a major health problem and a prime cause of global patient mortality throughout the world. Even after 90 years of vaccination and 60 years of advanced chemotherapy development, we are far away from eradicating the disease. All member states of the WHO and the UN pledged to eradicate TB by 2030 by reducing all TB deaths by 90% in the 2014 World Health Assembly. In developing nations and settings with limited resources, TB poses further challenges. Guide- Dr. Amit Misra, PhD Thesis Submitted to AcSIR , Ghaziabad, UP in 2019 by Ashish Srivastava 2019-08-22T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/1/1747 EXPLORING THE FUNCTIONAL SPECTRUM OF HOST DEFENCE PEPTIDES (HDPs) Raj, Sneha; Pasupuleti, Mukesh (Guide) Infectious diseases have been a leading cause of the threat to human existence. Starting from early records of 14th century till mid-20th century, a number of severe outbreaks have taken thousands of human lives in a very short span of time, e.g. the bubonic plague of Europe, which swiped away around one-third of its population, deadly massive epidemics of smallpox, influenza, dysentery and typhus that were frequent in the medieval era. In fact, the severity is described such that, at times, there was even lesser number of survivors in town to bury the dead and harvest crop for the season. With gradual learning amongst the people about hygiene and sanitary conditions of living, came an improvement and eradication of frequent plague outbreaks. Furthermore, several new antimicrobial agents were discovered at an accelerated pace and their applicability was found. The first antimicrobial agent in the world was Salvarsan which was the most prescribed therapeutic remedy for syphilis until the introduction of Penicillin. It was synthesized by Ehrlich, along with Alfred Bertheim and Sahachiro Hata in 1907. Guide- Dr. Mukesh Pasupuleti, PhD Thesis Submitted by Sneha Raj to JNU, New Delhi in 2019 2019-12-23T00:00:00Z